Effects of Phylogenetic Signal on Ancestral State Reconstruction
نویسندگان
چکیده
منابع مشابه
Robustness of Ancestral Sequence Reconstruction to Phylogenetic Uncertainty
Ancestral sequence reconstruction (ASR) is widely used to formulate and test hypotheses about the sequences, functions, and structures of ancient genes. Ancestral sequences are usually inferred from an alignment of extant sequences using a maximum likelihood (ML) phylogenetic algorithm, which calculates the most likely ancestral sequence assuming a probabilistic model of sequence evolution and ...
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Ancestral reconstruction is the extrapolation back in time from measured characteristics of individuals (or populations) to their common ancestors. It is an important application of phylogenetics, the reconstruction and study of the evolutionary relationships among individuals, populations, or species to their ancestors. In the context of biology, ancestral reconstruction can be used to recover...
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Molecular phylogenetic techniques do not generally account for such common evolutionary events as site insertions and deletions (known as indels). Instead tree building algorithms and ancestral state inference procedures typically rely on substitution-only models of sequence evolution. In practice these methods are extended beyond this simplified setting with the use of heuristics that produce ...
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ژورنال
عنوان ژورنال: Systematic Biology
سال: 2012
ISSN: 1076-836X,1063-5157
DOI: 10.1093/sysbio/syr124